| Application: | Enzyme Inhibition |
| Molecular Weight: | 100-500 |
| Research Area: | Histone Acetylation |
| Solubility: | DMSO |
| 100% Guarantee: | 6 months |
Alternative Names1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-oneDescriptionSplitomicin is a cell-permeable lactone that acts as a selective inhibitor of NAD+ dependent histone deacetylase activity of Sir2 protein. It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.CAS Number5690-03-9Chemical FormulaC13H10O2Molecular Weight198.2
Size5 mg
Purity≥98%SolubilityDMSOStorage Temp-20°C
